Pre-Ordini. I prossimi ordini partiranno dal 13 Maggio
DURO DURO
(come la coda di un canguro)
L'unico integratore per il DESIDERIO SESSUALE e il TESTOSTERONE con i Dosaggi SCIENTIFICI e Ingredienti Dimostrati
- Massima Qualità: ogni composto è un Estratto ed ha la propria PERCENTUALE di principio attivo (non semplici dosaggi alti o polveri generiche)
- Tutti i dosaggi giusti consigliati dagli studi scientifici (niente di sottodosato, come spesso accade)
- Nessun eccipiente o riempitivo inutile. Nessun macchinario industriale. La capsula è riempita al massimo a mano con quello che serve.
- Contiene tutti gli ingredienti provati e consigliati dagli studi in campo Libido (desiderio sessuale) e Testosterone nel 2024. Niente di inutile.
- Si abbina perfettamente ad integratori di Zinco, Magnesio, Dhea, Cialis, Citrullina, Vitamina D, Nac, Vitamina C, Creatina etc...
- Le capsule possono essere aperte e usate come polvere!
- L'integratore più completo e di qualità, al prezzo più basso del mercato
SCADENZA FEBBRAIO 2026!
Attenzione! Il composto è molto potente. È consigliabile prendere una pausa di 2-3 settimane ogni 3 mesi di assunzione!
*I primi effetti benefici si hanno entro 3 settimane dall'assunzione. I massimi entro i 3 mesi.
Puoi pagare anche in 3 rate su Paypal!
Quali sono gli INGREDIENTI?
A differenza di Brand che NON si basano sugli studi scientifici,
NON sono stati usati ingredienti:
- NON confermati scientificamente per la Libido/Testosterone (a livello di dosaggi, ciclizzazione, quantificazione dei benefici) e utilizzati SOLO come leve di MARKETING per Spillarti i soldi (come Muira Puama, Cordyceps, Cistanche salsa (può pure peggiorare la situazione), Acido D-Aspartico, Coleus Forskolii, Boro, Shilajit e potrei continuare....).
- Illegali in Italia e/o di non confermata efficacia (es. Tongkat Ali e Fadogia). Ad oggi, nella maggior parte dei casi, gli studi sono finanziati dai brand produttori.
- Riempitivi, Additivi, Eccipienti inutili per i Tuoi Risultati e potenzialmente pericolosi. "DURO DURO" è prodotto a mano e quindi non siamo costretti ad utilizzare quelle cose. Gli integratori industriali invece lo sono.
- Ingredienti privi della percentuale di principio attivo (standardizzazione). La materia prima senza percentuale è MOLTO più economica e MOLTO meno qualitativa (meno effetti) e per questo motivo molti brand la utilizzano (per guadagnare di più).
- No Vitamine o Minerali. Non hanno effetto su Libido o Testosterone, a meno che NON si sia carenti e in tal caso sono necessari integratori specifici a dosaggi MOLTO alti. In ottica invece di mantenimento/prevenzione, ho creato un integratore apposito: il "MULTIVITAMINICO SENZA STRONZ*TE", che contiene tutto il necessario nelle migliori forme e ai giusti dosaggi.
Non sono neanche stati utilizzati ingredienti che richiedono la prescrizione, come il Cialis e il Dhea.
*Se usciranno nuove informazioni, andrò ad aggiornare direttamente io l'integratore.
INGREDIENTI: Tribulus (Tribulus terrestris L.) frutto e.s. 1/10 d i cui 40% saponine, Ashwaganda KSM 66 (Whithania somnifera L. Dunal) radice, Fieno Greco (Trigonella Foenum Grecum L) semi estratto 1/50 di cui 50% saponine , Maca (Lepidium Meyenii Walp) radice e.s. 1/15 di cui 1 % glucosinolati, Zafferano (Crocus sativus L.) e.s. 1 / 5 d i cui 2% Safranale e 3% Crocine. Involucro: ipromellosa.
Dentro il pacco si riceverà una lettera con tutte le istruzioni su come utilizzare
al meglio l'integratore!
Vuoi le certificazioni e le analisi? Nessun problema. Scrivi a ufficio@baldiniedoardo.com
Perché è il MIGLIORE?
*non troverai da nessun'altra parte un composto con i giusti dosaggi e i giusti ingredienti insieme
Il fatto che DURO DURO
sia prodotto MANUALMENTE,
ti GARANTISCE di star assumendo un
vero e proprio
- Infatti mi garantisce piena libertà fomulativa e questo mi ha permesso di creare una formulazione esattamente come gli studi scientifici consigliano (nei processi industriali, che la maggior parte dei brand utilizza, questo non è possibile).
- Questo garantisce a te di avere i massimi benefici dall'integratore che utilizzi, dato che si rispetta i canoni DIMOSTRATI scientificamente.
- NON sei costretto ad ingurgitare ECCIPIENTI INUTILI o potenzialmente DANNOSI, perché NON dobbiamo inserirli. Nei processi produttivi industriali e quindi in molti prodotti dei GROSSI BRAND, l'utilizzo è obbligatorio per far funzionare i macchinari al meglio.
- Ogni capsula è riempita al massimo della sua capacità. Ti ritroverai quindi ad avere il massimo dosaggio per capsula e quindi a NON dover assumere capsule inutili e a NON dover pagare il costo extra delle capsule.
Quindi è vero che noi riusciamo a produrre SOLO 10 confezioni al giorno,
invece delle centinaia fabbricate dai grossi brand.
Questo però ti garantisce di assumere qualcosa
al 100% di Qualità.
Chi ne ha bisogno?
Se hai riscontrato:
- Un calo della Libido e della Vigorosità Sessuale.
- Un calo della rigidità dell'erezione derivante dall'abbassamento della Libido e del Testosterone.
- Un calo delle energie derivanti da un abbassamento del Testosterone.
- Maggior difficoltà a mettere massa derivante da un abbassamento del Testosterone.
- Maggior facilità ad accumulare grasso e maggior difficoltà a toglierlo derivante dall'abbassamento del Testosterone.
- Peggioramento dell'umore derivante dall'abbassamento del Testosterone.
- Una riduzione della produzione dello Sperma.
Se ci si ritrova in uno o più di questi punti,
"DURO DURO"
è l'integratore su cui puntare:
- per una migliore vita e desiderio sessuale (libido),
- per un maggior benessere generale (energia, umore, massa muscolare, perdita di grasso)
- per cercare di ottimizzare i livelli ormonali con potenziale incremento del Testosterone dal 10 al 40%
- e potenziale riduzione del Cortisolo (ormone dello stress) dal 20 al 50%.
Ogni Ingrediente ha la percentuale di Principio Attivo
Quando parliamo di ingredienti provenienti da piante,
se si vuole acquistare qualcosa di massima qualità
e soprattutto ottenere i massimi benefici:
- vogliamo un Estratto e NON la polvere di pianta. Esempio: vogliamo un estratto di Maca e NON la polvere di Maca.
- Vogliamo che vi sia scritta la Percentuale di Principio attivo. In "Duro Duro" per esempio la Maca è all'1% di Glucosinolati.
Quando per esempio parliamo di Zafferano, sono i suoi principi attivi a darci i benefici!
Non è il semplice dosaggio.
Dobbiamo quindi capire quanti ve ne siano.
Quando per esempio parliamo di Fieno Greco, sono le Saponine a darci i benefici
ed è la percentuale di esse che ci interessa!
Quando parliamo di Maca, sono di nuovo i suoi principi attivi a darci i benefici.
Non basta semplicemente mettere dosaggi alti di un composto scadente ed economico.
Vuoi il report? Scrivi a ufficio@baldiniedoardo.com
QUALI SONO I BENEFICI dei SINGOLI INGREDIENTI?
Lepidium Meyenii (Maca): una pianta originaria del Perù,
i cui benefici derivano dai suoi principi attivi.
A differenza di molti altri Integratori SPAZZATURA di MACA
che si trovano online e che magari hai acquistato in passato
ho selezionato una MACA in cui fosse presente la PERCENTUALE di PRINCIPIO ATTIVO
(è quella che leggi 1% glucosinolati).
Se una marca te la vende senza % del principio attivo. ATTENZIONE!
Hai quindi la tranquillità che sia di massima qualità
e in termini di BENEFICI gli studi ci dicono che possiamo aspettarci
- Incremento del Desiderio Sessuale (Libido) sia negli Uomini, che nelle Donne (anche senza problemi di salute)
- Potenziali benefici contro Disfunzione Erettile. Non è il campo più studiato, ma gli studi sembrano propendere per questo effetto.
IL COLORE della MACA è IMPORTANTE?
Contrariamente alle CAZZ*TE che potresti aver letto online o che potrebbero averti detto,
il colore della MACA è completamente irrilevante e non vi è una singola dimostrazione del contrario (rossa, nera o gialla sono uguali)
IL DOSAGGIO GIUSTO?
Siccome i benefici ad oggi risultano essere dose-dipendenti
e dato che:
ho deciso di inserire
un Estratto (non la schifezza di normale polvere) equivalente a:
4950mg di Pianta
che essendo in rapporto 15:1 è di
330mg
e come abbiamo detto prima,
deve essere chiarita la Percentuale di Principio attivo
ed in "DURO DURO" c'è ed è dell'1% in Glucosinolati
3,30mg di Glucosinolati
Oltre la Maca?
Una pianta le cui radici e frutti sono utilizzati da migliaia di anni fa nella medicina Ayurvedica e Cinese
e anche in questo caso i BENEFICI sono dati dai principi attivi.
Anche in questo caso ovviamente NON è stata inserita semplice polvere,
ma ho utilizzato un Estratto con % di principio attivo:
40% di Saponine!
e in termini di BENEFICI gli studi ci dicono che possiamo aspettarci
- Incremento del Desiderio Sessuale (Libido) sia negli Uomini, che nelle Donne,
- Aumento della Soddisfazione Sessuale
- e Riduzione dei sintomi Disfunzione Erettile (promuovendo il rilassamento dei tessuti del pene, aumentando la pressione intracavernosa e aumentando il flusso sanguigno nel pene per via di aumento dell'Ossido Nitrico)
IL DOSAGGIO GIUSTO?
Ho però preferito utilizzare il massimo quantitativo inseribile
in 4 capsule e quindi arrivare a:
1140mg (rapporto 10:1)
equivalente a:
11.400mg di Pianta
e come abbiamo detto prima,
deve essere chiarita la Percentuale di Principio attivo
ed in "DURO DURO" c'è il 40% di Saponine
456mg di Saponine
Questo perché comunque in qualche studio si superavano i 750mg.
Oltre alla MACA e al TRIBULUS?
Viene ritenuta la pianta per eccellenza della medicina Ayurvedica
(anche chiamata Ginseng Indiano).
Come per ogni pianta già vista, i BENEFICI sono dati dal principio attivo.
Sono riuscito ad ottenere, direttamente dal brand KSM 66, l'autorizzazione a poter
utilizzare la loro materia prima e il loro marchio.
Materia prima che è fra le più utilizzate negli studi scientifici
e che GARANTISCE il 5% del principio attivo (Withanolidi).
In termini di benefici che ci si può aspettare:
- Incremento del Testosterone sia in soggetti con livelli bassi (esempio: uomini infertili), che con livelli nella norma, buoni. Stando agli studi, abbiamo un minimo di incremento dal 10%, fino ad un massimo del 40%.
- Protezione dei Testicoli dallo stress ossidativo (antiossidante) che altrimenti può compromettere il corretto funzionamento. Quindi: + Quantità + Motilità + Qualità e + Vitalità dello Sperma.
- Abbassamento del Cortisolo (ormone dello stress) che può impattare negativamente su Testosterone e Libido. Ad oggi si presuppone una riduzione dal 20 al 50%.
- Incremento Libido e Corretto Funzionamento Sessuale sia negli uomini, che nelle donne.
- Potenziale miglioramento della Qualità e Quantità del Sonno (soggetti con insonnia e non), riduzione dell'Ansia (anche da Prestazione Sessuale), Protezione del Cervello e dell'apparato cognitivo.
- Potenziale miglioramento delle Prestazioni Sportive di Forza e Resistenza/Endurance (in soggetti neofiti e non) e potenziale miglioramento del recupero.
PERCHÈ PROPRIO L'ASHWAGANDHA?
Ad oggi NON esistono composti provati scientificamente al 100% andare ad aumentare il Testosterone.
O meglio, molto spesso non si riesce a quantificare
l'entità dei benefici in soggetti sani e non
o non si riesce a stabilire un protocollo di assunzione
(dosaggi, tempistiche, qualità etc...).
Bene l'Ashwagandha, fra tutti i composti, è quello su cui abbiamo più materiale e quindi
NON può mancare
in un composto che abbia l'obiettivo di ottimizzare i propri livelli di Testosterone.
È fondamentale che però vi sia il quantitativo giusto!
IL DOSAGGIO GIUSTO?
I benefici fino a quando non si raggiungono
i 600mg risultano essere dose-dipendenti.
Ciò significa che i brand che utilizzano 80,100,200mg vendono qualcosa di
NON adeguato e NON funzionante.
Superati i 600mg invece non risultano esserci più benefici.
Per questo motivo ho utilizzato
Esattamente 600mg
di materia prima altissima e certificata
KSM 66 al 5% di Whitanolidi
NON tutti possono utilizzarla.
È necessario ricevere approvazione della propria formulazione dal fornitore.
Questa materia prima è proprio la stessa che la maggior parte degli studi utilizza.
Una Percentuale di Whitanolidi maggiore
non sarebbe stata meglio?
Stando alle informazioni scientifiche, ad oggi,
NON conosciamo la percentuale giusta di principio attivo.
Quello che sappiamo è che la maggior parte degli studi
utilizzava 600mg e che dosaggi maggiori NON sembrerebbero
dare benefici in più.
Oltre a ciò, la maggior parte degli studi ha utilizzato
il 5% di principio attivo.
Per questo motivo, in assenza di ulteriori informazioni,
è stata utilizzata la migliore materia prima certificata.
E quindi NO una percentuale maggiore, ad oggi,
NON è superiore.
Gli Ingredienti NON sono finiti...
Trigonella foenum-graecum o Fieno Greco
Ha diversi principi attivi fra cui Flavonoidi, Acidi Fenolici, Alcaloidi flavonoids e le più importanti le Saponine Steroidee.
È fondamentale anche per questo ingrediente vi sia scritta la percentuale di principio attivo (da cui, come hai capito ormai, otteniamo i benefici).
In termini di benefici che ci si può aspettare:
- Potenziale incremento del Testosterone Totale e Libero si ritiene che derivi da un blocco dell'aromatasi (quindi minor conversione del Testosterone in Estrogeni. Quindi + Testosterone Libero). Questo sia in soggetti allenati, che non e sia in soggetti con livelli bassi, che non.
- Incremento della Libido e Funzionamento Sessuale (si presuppone come conseguenza dell'aumento del Testosterone). Questi benefici sono stati visti sia negli Uomini, che nelle Donne. Ancora di più a partire dai 40 anni.
- Bonus: può contrastare la caduta dei capelli (sì è vista una riduzione di circa il 9% in termini di conversione del Testosterone in DHT, l'ormone coinvolto nella caduta dei capelli o quantomeno può essere un'altra ragione per cui si possa avere + Testosterone Libero).
- Bonus: abbassa i livelli degli zuccheri nel sangue (sembrerebbe al pari, se non di più della Berberina. Per questo motivo, considerando anche che in "Duro Duro" vi è lo Zafferano, che aiuta anch'esso, potrebbe non aver senso assumere la Berberina).
IL DOSAGGIO GIUSTO?
Se un brand ti mette dosaggi inferiori a questi, sai che NON segue le linee guida scientifiche e che quindi NON funzionerà.
Ovviamente io ho rispettato i dosaggi e infatti trovi
Esattamente 600mg
con il principio attivo scritto, che è del
50% in Saponine
Non è ancora finita...
Ne avrai già sentito parlare, è la spezia più costosa.
Anche in questo caso però non è della normale polvere
(come quella che potresti utilizzare in cucina).
È un estratto e non semplice polvere (quindi migliore),
ma NON uno qualsiasi...
... un estratto con DOPPIA % di principio attivo specificato
(perché è ciò che ci da i benefici)
La maggior parte dei brand NON lo utilizza perché è un ingrediente
MOLTO più costoso di un semplice estratto generico
o di un estratto con solo una percentuale.
In termini di effetti benefici ci si può aspettare:
- Potenziale Miglioramento della qualità delle Erezioni e della Libido (uomo e donna).
- Miglioramento dell'Umore e Abbassamento dell'Ansia e dello Stress (vedi abbassamento del Cortisolo). Gli effetti sono così importanti da essere paragonabili a quelli di farmaci. Tutto questo può tornare molto utile a coloro che si ritrovano ad avere bassa libido o problemi di erezione derivanti da problemi di umore o di ansia. Può essere utile per chi soffra di ansia da prestazione. Può essere utile per chi ha un abbassamento dei livelli di Testosterone causati dallo Stress/Cortisolo.
- Bonus: abbassa i livelli di zuccheri nel sangue se troppo alti: meno efficace di Berberina e Fieno Greco, ma considerando che in "Duro Duro" è presente il Fieno Greco, questo + lo Zafferano rendono potenzialmente NON necessario l'utilizzo di Berberina.
IL DOSAGGIO GIUSTO?
Per questo motivo ho utilizzato proprio
30mg da utilizzare in 2 assunzioni giornaliere
con i principi attivi specificati, per i massimi benefici
che sono del
2% in Safranale
e 3% in Crocine
Perché non ci sono altri ingredienti?
Come già spiegato, negli integratori scientifici di massima qualità, vogliamo trovare:
- SOLO ingredienti provati o comunque "solidi" a livello scientifico (sicuramente in futuro vi sarà nuovo materiale e la formula sarà aggiornata. Per il momento è perfetta).
- Gli ingredienti ai giusti dosaggi. Non vogliamo infatti trovare tanti ingredienti sottodosati. Vogliamo quelli giusti e ai livelli efficaci.
- Ovviamente NON vogliamo eccipienti o riempitivi vari che possono essere inutili o addirittura dannosi!
Se hai sentito parlare di integratori "rivoluzionari": o non funzionano o non hanno dimostrazioni scientifiche sufficienti.
Hai il mio MULTIVITAMINICO SENZA STRONZ*TE?
OTTIMO! Sono Complementari!
Il "Duro Duro" e il
"Multivitaminico Senza Stronz*te"
sono stati pensati per lavorare insieme!
- Nel "Multivitaminico senza Stronz*te" troviamo Zinco, Magnesio e Vitamina D. Questi 3 composti, in caso di carenza, possono portare ad un abbassamento della Libido e del Testosterone. Andandolo a prendere ci assicuriamo di non finire per diventarlo e di conseguenza far si che "Duro Duro" funzioni al meglio senza intoppi.
Hai il mio ANTIOSSIDANTE SENZA STRONZ*TE?
OTTIMO! Sono Complementari!
Il "Duro Duro" e
"Antiossidante senza stronz*te"
sono stati pensati per lavorare insieme!
- Nel "Antiossidante Senza Stronz*te" troviamo Vitamina C e Nac. Entrambi proteggono il corpo dallo stress e dal danno ossidativo (causati dallo stress quotidiano, dall'aria inquinata, dal cibo di minor qualità etc...). Più nello specifico, parlando di Libido e Testosterone, ci interessa per la protezione dei testicoli, in modo che ne preservino il corretto funzionamento e produzione ormonale (Testosterone).
Domande Frequenti
Sì, è adatto ai vegani ed è senza lattosio. Ci possono essere delle tracce di glutine.
Sì, la spedizione è tracciata e il pacco verrà consegnato in 2 giorni lavorativi dal giorno dell'ordine.
Contrassegno: non è possibile pagare con il contrassegno.
Bonifico: È possibile. I dati sono i seguenti.
Farmacia degli Ulivi s.r.l.
BANCO INTESA SANPAOLO
IBAN: IT93 T03069 64716 1000 0000 4961
Appena fatto invia la contabile a questa email: ufficio@baldiniedoardo.com
La data di scadenza è 1 anno dall'acquisto
Sì, va bene per entrambi. Tutte le persone hanno bisogno di tutelare la propria salute.
Puoi scrivere a questo numero +393339118811 o a questa email ufficio@baldiniedoardo.com
Puoi scrivere una email a ufficio@baldiniedoardo.com o un messaggio whatsapp al +393339118811.
Idealmente lo vuoi prendere in 2 assunzioni giornaliere con un pasto. Riceverai però tutte le istruzioni dentro il pacco.
Avrai accesso ad un'email riservata per il supporto specifico a questo integratore.
Sì, dai 14 anni in su va bene per ogni età!
Quali Studi sono stati usati?
Il quantitativo di studi utilizzati per la creazione di
"Duro Duro"
richiederebbe un sito apposito.
Qui di seguito però ti lascio i principali,
oltre a quelli già mostrati in questa pagina:
^Beharry S, Heinrich MIs the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified?J Ethnopharmacol.(2018-Jan-30)
^Gonzales GF, Córdova A, Vega K, Chung A, Villena A, Góñez C, Castillo SEffect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy menAndrologia.(2002 Dec)
^Dording CM, Schettler PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, Fava M, Mischoulon DA double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in womenEvid Based Complement Alternat Med.(2015)
^Stojanovska L, Law C, Lai B, Chung T, Nelson K, Day S, Apostolopoulos V, Haines CMaca reduces blood pressure and depression, in a pilot study in postmenopausal womenClimacteric.(2015 Feb)
^Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan IA, Gonzales GFAcceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel).(2016 Aug 18)
^Lee HW, Lee MS, Qu F, Lee JW, Kim EMaca ( Walp) on semen quality parameters: A systematic review and meta-analysis.Front Pharmacol.(2022)
^Valentová K, Buckiová D, Kren V, Peknicová J, Ulrichová J, Simánek VThe in vitro biological activity of Lepidium meyenii extracts.Cell Biol Toxicol.(2006-Mar)
^Lee MS, Shin BC, Yang EJ, Lim HJ, Ernst EMaca (Lepidium meyenii) for treatment of menopausal symptoms: A systematic review.Maturitas.(2011-Nov)
^Zhang Y, Rants'o TA, Jung D, Lopez E, Abbott K, Pondugula SR, McLendon L, Qian J, Hansen RA, Calderón AIScreening for CYP3A4 inhibition and induction coupled to parallel artificial membrane permeability assay (PAMPA) for prediction of botanical-drug interactions: The case of açaí and maca.Phytomedicine.(2019-Jun)
^Meissner HO, Reich-Bilinska H, Mscisz A, Kedzia BTherapeutic Effects of Pre-Gelatinized Maca (Lepidium Peruvianum Chacon) used as a Non-Hormonal Alternative to HRT in Perimenopausal Women - Clinical Pilot Study.Int J Biomed Sci.(2006-Jun)
^Capuano E, Oliviero T, Fogliano V, Pellegrini NRole of the food matrix and digestion on calculation of the actual energy content of food.Nutr Rev.(2018-Apr-01)
^Gonzales GFEthnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands.Evid Based Complement Alternat Med.(2012)
^Valerio LG, Gonzales GFToxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis.Toxicol Rev.(2005)
^Progesterone - Meissner HO, Mscisz A, Reich-Bilinska H, Mrozikiewicz P, Bobkiewicz-Kozlowska T, Kedzia B, Lowicka A, Barchia IHormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient studyInt J Biomed Sci.(2006 Dec)
^Progesterone - Meissner HO, Mscisz A, Reich-Bilinska H, Kapczynski W, Mrozikiewicz P, Bobkiewicz-Kozlowska T, Kedzia B, Lowicka A, Barchia IHormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (II) Physiological and Symptomatic Responses of Early-Postmenopausal Women to Standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre Clinical StudyInt J Biomed Sci.(2006 Dec)
^Progesterone - Tsuyoshi Takewaka, Kiyoshi HaraClinical Effect of Oral Administration of Maca (Lepidium meyenii) Extract on Japanese Peri-Menopausal Women Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyInt J Biomed Sci.()
Progesterone - Meissner HO, Kapczynski W, Mscisz A, Lutomski JUse of gelatinized maca (lepidium peruvianum) in early postmenopausal womenInt J Biomed Sci.(2005 Jun)
^Chronic Mountain Sickness Symptoms - Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan IA, Gonzales GFAcceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel).(2016 Aug 18)
^Estrogen - Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska LBeneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen contentMenopause.(2008 Nov-Dec)
^Testosterone - Gonzales GF, Córdova A, Vega K, Chung A, Villena A, Góñez C, Castillo SEffect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy menAndrologia.(2002 Dec)
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High-density lipoprotein (HDL) - Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VSEffects of Withania somnifera in patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial studyIndian J Pharmacol.(2013 Jul)
Schizophrenia symptoms - Chengappa KNR, Brar JS, Gannon JM, Schlicht PJAdjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled StudyJ Clin Psychiatry.(2018 Jul 10)
Testosterone - Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya SExamining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trialJ Int Soc Sports Nutr.(2015 Nov 25)
White Blood Cell Count - Raut AA, Rege NN, Tadvi FM, Solanki PV, Kene KR, Shirolkar SG, Pandey SN, Vaidya RA, Vaidya ABExploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteersJ Ayurveda Integr Med.(2012 Jul)
Oxygen Uptake - Sandhu JS, Shah B, Shenoy S, Chauhan S, Lavekar GS, Padhi MMEffects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adultsInt J Ayurveda Res.(2010 Jul)
Oxidative Stress Biomarkers - Kuchewar VV, Borkar MA, Nisargandha MAEvaluation of antioxidant potential of Rasayana drugs in healthy human volunteersAyu.(2014 Jan)
Red Blood Cell Count - Ziegenfuss TN, Kedia AW, Sandrock JE, Raub BJ, Kerksick CM, Lopez HLEffects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR TrialNutrients.(2018 Nov 20)
Oxygen Uptake - Shenoy S, Chaskar U, Sandhu JS, Paadhi MMEffects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclistsJ Ayurveda Integr Med.(2012 Oct)
vLDL-C - Auddy, B, et alA Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled StudyJ Am Nut Assn.()
Heart Rate - Choudhary D, Bhattacharyya S, Joshi KBody Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled TrialJ Evid Based Complementary Altern Med.(2017 Jan)
Stress Signs and Symptoms - Camellia Akhgarjand, Farzaneh Asoudeh, Amir Bagheri, Zahra Kalantar, Zahra Vahabi, Sakineh Shab-Bidar, Hamid Rezvani, Kurosh DjafarianDoes Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trialsPhytother Res.(2022 Aug 25)
Testosterone - Gupta A, Mahdi AA, Shukla KK, Ahmad MK, Bansal N, Sankhwar P, Sankhwar SNEfficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHzJ Ethnopharmacol.(2013 Aug 26)
Testosterone - Abbas Ali Mahdi, Kamla Kant Shukla, Mohammad Kaleem Ahmad, Singh Rajender, Satya Narain Shankhwar, Vishwajeet Singh, Deepansh DalelaWithania somnifera Improves Semen Quality in Stress-Related Male FertilityEvid Based Complement Alternat Med.(2009 Sep 29)
Testosterone - Ahmad MK, Mahdi AA, Shukla KK, Islam N, Rajender S, Madhukar D, Shankhwar SN, Ahmad SWithania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile malesFertil Steril.(2010 Aug)
Testosterone - Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre AClinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot StudyEvid Based Complement Alternat Med.(2013)
Sperm Quality - Nasimi Doost Azgomi R, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nejatbakhsh F, Moini Jazani A, Ahmadi AsrBadr Y, Zomorrodi AComparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trialAndrologia.(2018 Sep)
Anxiety Symptoms - Andrade C, Aswath A, Chaturvedi SK, Srinivasa M, Raguram RA double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somniferaIndian J Psychiatry.(2000 Jul)
Anxiety Symptoms - Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar DEfficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled StudyCureus.(2019 Sep 28)
Anxiety Symptoms - K Chandrasekhar, Jyoti Kapoor, Sridhar AnishettyA prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adultsIndian J Psychol Med.(2012 Jul)
Anxiety Symptoms - Cooley K, Szczurko O, Perri D, Mills EJ, Bernhardt B, Zhou Q, Seely DNaturopathic care for anxiety: a randomized controlled trial ISRCTN78958974PLoS One.(2009 Aug 31)
Anxiety Symptoms - Salve J, Pate S, Debnath K, Langade DAdaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical StudyCureus.(2019 Dec 25)
Bipolar Disorder Symptoms - Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal RRandomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorderJ Clin Psychiatry.(2013 Nov)
Working Memory - Choudhary D, Bhattacharyya S, Bose SEfficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive FunctionsJ Diet Suppl.(2017 Nov 2)
Reaction Time - Pingali U, Pilli R, Fatima NEffect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participantsPharmacognosy Res.(2014 Jan)
Subjective Well-Being - Sud Khyati S, Thaker Anup BA RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY OF ASHWAGANDHA ON GENERALIZED ANXIETY DISORDERInternational Ayurvedic Medical Journal .()
Fatigue Symptoms - Adrian L Lopresti, Peter D Drummond, Stephen J SmithA Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight MalesAm J Mens Health.(Mar-Apr 2019)
Erections - Mamidi P, Thakar ABEfficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunctionAyu.(2011 Jul)
Thyroid-Stimulating Hormone - Sharma AK, Basu I, Singh SEfficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled TrialJ Altern Complement Med.(2018 Mar)
Cortisol - Lopresti AL, Smith SJ, Malvi H, Kodgule RAn investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled studyMedicine (Baltimore).(2019 Sep)
Natural Killer Cell Activity - Jeremy Mikolai, Andrew Erlandsen, Andrew Murison, Kimberly A Brown, William L Gregory, Padma Raman-Caplan, Heather L ZwickeyIn vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytesJ Altern Complement Med.(2009 Apr)
OCD Symptoms - Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, Gholampour B, Mohammadpour AH, Sahebkar AEvaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trialComplement Ther Med.(2016 Aug)
Sexual Function - Dongre S, Langade D, Bhattacharyya SEfficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot StudyBiomed Res Int.(2015)
Pain - Ramakanth GS, Uday Kumar C, Kishan PV, Usharani PA randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint painJ Ayurveda Integr Med.(2016 Jul - Sep)
Blood glucose - B Andallu, B RadhikaHypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) rootIndian J Exp Biol.(2000 Jun)
Quality of Life - Choudhary B, Shetty A, Langade DGEfficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adultsAyu.(2015 Jan-Mar)
Insomnia Signs and Symptoms - Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KIEffect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patientsIntegr Cancer Ther.(2013 Jul)
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Insulin - Chevassus H, Gaillard JB, Farret A, Costa F, Gabillaud I, Mas E, Dupuy AM, Michel F, Cantié C, Renard E, Galtier F, Petit PA fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjectsEur J Clin Pharmacol.(2010 May)
Appetite - Chevassus H, Molinier N, Costa F, Galtier F, Renard E, Petit PA fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteersEur J Clin Pharmacol.(2009 Dec)
Blood glucose - Kochhar A, Nagi MEffect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot studyJ Med Food.(2005 Winter)
Blood glucose - Losso JN, Holliday DL, Finley JW, Martin RJ, Rood JC, Yu Y, Greenway FLFenugreek bread: a treatment for diabetes mellitusJ Med Food.(2009 Oct)
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Prostate Specific Antigen - Steels E, Rao A, Vitetta LPhysiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral FormulationPhytother Res.(2011 Feb 10)
Glycogen Resynthesis - Ruby BC, Gaskill SE, Slivka D, Harger SGThe addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exerciseAmino Acids.(2005 Feb)
Glycogen Resynthesis - Slivka D, Cuddy J, Hailes W, Harger S, Ruby BGlycogen resynthesis and exercise performance with the addition of fenugreek extract (4-hydroxyisoleucine) to post-exercise carbohydrate feedingAmino Acids.(2008 Aug)
Milk Production - Vida Ghasemi, Masoomeh Kheirkhah, Mohsen VahediThe Effect of Herbal Tea Containing Fenugreek Seed on the Signs of Breast Milk Sufficiency in Iranian Girl InfantsIran Red Crescent Med J.(2015 Aug 15)
Milk Production - Reena Ravi, Jasmine JosephEffect of fenugreek on breast milk production and weight gain among Infants in the first week of lifeClinical Epidemiology and Global Health.()
Milk Production - Siew Cheng Foong, May Loong Tan, Wai Cheng Foong, Lisa A Marasco, Jacqueline J Ho, Joo Howe OngOral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infantsCochrane Database Syst Rev.(2020 May 18)
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Milk Production - Turkyılmaz C, Onal E, Hirfanoglu IM, Turan O, Koç E, Ergenekon E, Atalay YThe effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of lifeJ Altern Complement Med.(2011 Feb)
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^Wang H, Jin M, Xie M, Yang Y, Xue F, Li W, Zhang M, Li Z, Li X, Jia N, Liu Y, Cui X, Hu G, Dong L, Wang G, Yu QProtective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.J Affect Disord.(2023-Feb-15)
^Sadat Rafiei SK, Abolghasemi S, Frashidi M, Ebrahimi S, Gharei F, Razmkhah Z, Tavousi N, Mahmoudvand B, Faani M, Karimi N, Abdi A, Soleimanzadeh M, Ahmadpour Youshanlui M, Sadatmadani SF, Alikhani R, Pishkari Y, Deravi NSaffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials.Nutr Metab Insights.(2023)
^Cerdá-Bernad D, Costa L, Serra AT, Bronze MR, Valero-Cases E, Pérez-Llamas F, Candela ME, Arnao MB, Barberán FT, Villalba RG, García-Conesa MT, Frutos MJSaffron against Neuro-Cognitive Disorders: An Overview of Its Main Bioactive Compounds, Their Metabolic Fate and Potential Mechanisms of Neurological Protection.Nutrients.(2022 Dec 17)
^Abedi A, Ghobadi H, Sharghi A, Iranpour S, Fazlzadeh M, Aslani MREffect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials.Front Med (Lausanne).(2023)
^Wolfgang Marx, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka, Olivia M DeanEffect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysisNutr Rev.(2019 May 28)
^Lili Dai, Lingyan Chen, Wenjing WangSafety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysisJ Nerv Ment Dis.(2020 Apr)
^Musazadeh V, Zarezadeh M, Faghfouri AH, Keramati M, Ghoreishi Z, Farnam ASaffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis.Pharmacol Res.(2022-Jan)
^Bostan HB, Mehri S, Hosseinzadeh HToxicology effects of saffron and its constituents: a review.Iran J Basic Med Sci.(2017-Feb)
^Safarinejad MR, Shafiei N, Safarinejad SA prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermiaPhytother Res.(2011 Apr)
^Aissa R, Ibourki M, Ait Bouzid H, Bijla L, Oubannin S, Sakar EH, Jadouali S, Hermansyah A, Goh KW, Ming LC, Bouyahya A, Gharby SPhytochemistry, quality control and medicinal uses of Saffron (.): an updated review.J Med Life.(2023-Jun)
^Seyedi-Sahebari S, Farhang S, Araj-Khodaei M, Akhondzadeh S, Naseri A, Sanaie S, Frounchi NThe Effects of (Saffron) on ADHD: A Systematic Review.J Atten Disord.(2024-Jan)
^Moini Jazani A, Karimi A, Nasimi Doost Azgomi RThe potential role of saffron (Crocus Sativus L.) and its components in oxidative stress in diabetes mellitus: A systematic review.Clin Nutr ESPEN.(2022-Apr)
^Hamedani SG, Pourmasoumi M, Zarifi SH, Askari G, Jamialahmadi T, Bagherniya M, Sahebkar ATherapeutic effects of saffron and its components on neurodegenerative diseases.Heliyon.(2024-Jan-30)
^Jinrong Lian, Yi Zhong, Hang Li, Siyuan Yang, Jiahe Wang, Xiang Li, Xinmin Zhou, Gang ChenEffects of saffron supplementation on improving sleep quality: a meta-analysis of randomized controlled trialsSleep Med.(2022 Apr)
^Munirah MP, Norhayati MN, Noraini MCrocus Sativus for Insomnia: A Systematic Review and Meta-Analysis.Int J Environ Res Public Health.(2022-Sep-16)
^Masaki M, Aritake K, Tanaka H, Shoyama Y, Huang ZL, Urade YCrocin promotes non-rapid eye movement sleep in mice.Mol Nutr Food Res.(2012-Feb)
^Hosseinzadeh H, Noraei NBAnxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice.Phytother Res.(2009-Jun)
^Blasco-Fontecilla H, Moyano-Ramírez E, Méndez-González O, Rodrigo-Yanguas M, Martin-Moratinos M, Bella-Fernández MEffectivity of Saffron Extract (Saffr'Activ) on Treatment for Children and Adolescents with Attention Deficit/Hyperactivity Disorder (ADHD): A Clinical Effectivity Study.Nutrients.(2022-Sep-28)
^Sara Baziar, Ali Aqamolaei, Ebrahim Khadem, Seyyed Hosein Mortazavi, Sina Naderi, Erfan Sahebolzamani, Amirhosein Mortezaei, Shakiba Jalilevand, Mohammad-Reza Mohammadi, Mahsa Shahmirzadi, Shahin AkhondzadehCrocus sativus L. Versus Methylphenidate in Treatment of Children with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot StudyJ Child Adolesc Psychopharmacol.(2019 Apr)
^Khaksarian M, Ahangari N, Masjedi-Arani A Mirr I , Jafari H , Kordian S, Nooripour R, Hassanvandi SA comparison of methylphenidate (MPH) and combined methylphenidate with Crocus sativus (saffron) in the treatment of children and adolescents with ADHD: A randomized, double-blind, parallel-group, clinical trialIran J Psychiatry Behav Sci.(2021 May)
^Pazoki B, Zandi N, Assaf Z, Moghaddam H, Zeinoddini A, Mohammadi M, Akhondzadeh SEfficacy and safety of saffron as adjunctive therapy in adults with attention-deficit/hyperactivity disorder: A randomized, double-blind, placebo-controlled clinical trialAdv Integr Med.(2022 Mar)
^Mohammad Zamani, Mahtab Zarei, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Amir Mehdi Hosseini, Maryam Nadery, Farideh Shiraseb, Omid AsbaghiThe effects of saffron supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysisFront Nutr.(2022 Dec 8)
^Maleki-Saghooni N, Mirzaeii K, Hosseinzadeh H, Sadeghi R, Irani MA systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters.Avicenna J Phytomed.(2018 May-Jun)
^Ranjbar H, Ashrafizaveh AEffects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis.Avicenna J Phytomed.(2019 Sep-Oct)
^Concerto C, Rodolico A, Meo V, Chiappetta D, Bonelli M, Mineo L, Saitta G, Stuto S, Signorelli MS, Petralia A, Lanza G, Aguglia EA Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications.Curr Issues Mol Biol.(2022-Jul-25)
^Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi ASaffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trialJ Clin Pharm Ther.(2010 Oct)
^Akhondzadeh S, Shafiee Sabet M, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SS, Yousefi MH, Alimardani R, Jamshidi A, Rezazadeh SA, Yousefi A, Zare F, Moradi A, Vossoughi AA 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's diseasePsychopharmacology (Berl).(2010 Jan)
^Mehdi Farokhnia, Mehdi Shafiee Sabet, Negar Iranpour, Amirhossein Gougol, Habibeh Yekehtaz, Roozbeh Alimardani, Farzaneh Farsad, Maryam Kamalipour, Shahin AkhondzadehComparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trialHum Psychopharmacol.(2014 Jul)
^Avgerinos KI, Vrysis C, Chaitidis N, Kolotsiou K, Myserlis PG, Kapogiannis DEffects of saffron (Crocus sativus L.) on cognitive function. A systematic review of RCTs.Neurol Sci.(2020-Oct)
^Sepahi S, Ghorani-Azam A, Hossieni SM, Mohajeri SA, Khodaverdi EPharmacological Effects of Saffron and its Constituents in Ocular Disorders from in vitro Studies to Clinical Trials: A Systematic Review.Curr Neuropharmacol.(2021)
^Butnariu M, Quispe C, Herrera-Bravo J, Sharifi-Rad J, Singh L, Aborehab NM, Bouyahya A, Venditti A, Sen S, Acharya K, Bashiry M, Ezzat SM, Setzer WN, Martorell M, Mileski KS, Bagiu IC, Docea AO, Calina D, Cho WCThe Pharmacological Activities of L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents.Oxid Med Cell Longev.(2022)
Insomnia Signs and Symptoms - Adrian L Lopresti, Stephen J Smith, Alexandra P Metse, Peter D DrummondEffects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trialJ Clin Sleep Med.(2020 Jun 15)
Anxiety Symptoms - Amir Ghaderi, Omid Asbaghi, Željko Reiner, Fariba Kolahdooz, Elaheh Amirani, Hamed Mirzaei, Hamid Reza Banafshe, Parisa Maleki Dana, Zatollah AsemiThe effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trialsComplement Ther Med.(2020 Jan)
Anxiety Symptoms - Shahdadi H, Balouchi A, Dehghanmehr S Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental studyTrop J Pharm Res.()
Anxiety Symptoms - Graham Kell, Amanda Rao, Gavin Beccaria, Paul Clayton, Antonio Manuel Inarejos-García, Marin Prodanovaffron ® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trialComplement Ther Med.(2017 Aug)
Sleep Quality - Jinrong Lian, Yi Zhong, Hang Li, Siyuan Yang, Jiahe Wang, Xiang Li, Xinmin Zhou, Gang ChenEffects of saffron supplementation on improving sleep quality: a meta-analysis of randomized controlled trialsSleep Med.(2022 Apr)
Lactate Dehydrogenase - Ghanbari-Niaki A, et alEffect of Crocus Sativus Linnaeus (saffron) supplementations combined with circuit resistance training on total creatine kinase, lactate dehydrogenase and creatine kinase MB levels in young untrained menScience & Sports.()
Muscle Soreness - Meamarbashi A, Rajabi APreventive effects of 10-day supplementation with saffron and indomethacin on the delayed-onset muscle sorenessClin J Sport Med.(2015 Mar)
Blood Pressure - Mostafa Asadollahi, Parisa Nikdokht, Boshra Hatef, Seyed Shahabeddin Sadr, Hedayat Sahraei, Farhad Assarzadegan, Gila Pirzad JahromiProtective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trialJ Ethnopharmacol.(2019 Jun 28)
Creatinine - Kianbakht S, Ghazavi AImmunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trialPhytother Res.(2011 Dec)
TNF-Alpha - Hajieh Shahbazian, Armaghan Moravej Aleali, Reza Amani, Foroogh Namjooyan, Bahman Cheraghian, Seyed Mahmoud Latifi, Sara Bahrainian, Ataallah GhadiriEffects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trialAvicenna J Phytomed.(Sep-Oct 2019)
Triglycerides - Nasim Abedimanesh, S Zahra Bathaie, Saeed Abedimanesh, Behrooz Motlagh, Ahmad Separham, Alireza OstadrahimiSaffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery diseaseJ Cardiovasc Thorac Res.(2017)
Triglycerides - Milajerdi A, Jazayeri S, Hashemzadeh N, Shirzadi E, Derakhshan Z, Djazayeri A, Akhondzadeh SThe effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trialJ Res Med Sci.(2018 Feb 20)
Weight - Gout B, Bourges C, Paineau-Dubreuil SSatiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy womenNutr Res.(2010 May)
Visual acuity (VA) - Dario Marangoni, Benedetto Falsini, Marco Piccardi, Lucia Ambrosio, Angelo Maria Minnella, Maria Cristina Savastano, Silvia Bisti, Rita Maccarone, Antonello Fadda, Enrica Mello, Paola Concolino, Ettore CapoluongoFunctional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary reportJ Transl Med.(2013 Sep 25)
Visual acuity (VA) - Geoffrey K Broadhead, John R Grigg, Peter McCluskey, Thomas Hong, Timothy E Schlub, Andrew A ChangSaffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trialGraefes Arch Clin Exp Ophthalmol.(2019 Jan)
Retinal Function - Alireza Lashay, Gholamreza Sadough, Elham Ashrafi, Mohammadreza Lashay, Morteza Movassat, Shahin AkhondzadehShort-term Outcomes of Saffron Supplementation in Patients with Age-related Macular Degeneration: A Double-blind, Placebo-controlled, Randomized TrialMed Hypothesis Discov Innov Ophthalmol.(Spring 2016)
HbA1c - Mohammad Zamani, Mahtab Zarei, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Amir Mehdi Hosseini, Maryam Nadery, Farideh Shiraseb, Omid AsbaghiThe effects of saffron supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysisFront Nutr.(2022 Dec 8)
High-density lipoprotein (HDL) - Jamal Rahmani, Nicla Manzari, Jacqueline Thompson, Cain C T Clark, Gemma Villanueva, Hamed Kord Varkaneh, Parvin MirmiranThe effect of saffron on weight and lipid profile: A systematic review, meta-analysis, and dose-response of randomized clinical trialsPhytother Res.(2019 Sep)
Depression Symptoms - Omid Asbaghi, Sepideh Soltani, Noushin Norouzi, Alireza Milajerdi, Saeed Choobkar, Zatollah AsemiThe effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trialsComplement Ther Med.(2019 Dec)
LDL Oxidation - S K Verma, A BordiaAntioxidant property of Saffron in manIndian J Med Sci.(1998 May)
Anxiety Symptoms - Wolfgang Marx, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka, Olivia M DeanEffect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysisNutr Rev.(2019 May 28)
Anxiety Symptoms - A Ghajar, S M Neishabouri, N Velayati, L Jahangard, N Matinnia, M Haghighi, A Ghaleiha, M Afarideh, S Salimi, A Meysamie, S AkhondzadehCrocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical TrialPharmacopsychiatry.(2017 Jul)
Anxiety Symptoms - Alireza Milajerdi, Shima Jazayeri, Elham Shirzadi, Najmeh Hashemzadeh, Atieh Azizgol, Abolghassem Djazayery, Ahmad Esmaillzadeh, Shahin AkhondzadehThe effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trialComplement Ther Med.(2018 Dec)
Anxiety Symptoms - Ehsan Moazen-Zadeh, Seyed Hesameddin Abbasi, Hamideh Safi-Aghdam, Nazila Shahmansouri, Akram Arjmandi-Beglar, Azita Hajhosseinn Talasaz, Abbas Salehiomran, Saeedeh Forghani, Shahin AkhondzadehEffects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled TrialJ Altern Complement Med.(2018 Apr)
Anxiety Symptoms - Adrian L Lopresti, Peter D Drummond, Antonio M Inarejos-García, Marin Prodanovaffron ®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled studyJ Affect Disord.(2018 May)
Anxiety Symptoms - Mohsen Mazidi, Maryam Shemshian, Seyed Hadi Mousavi, Abdolreza Norouzy, Tayebe Kermani, Toktam Moghiman, Akram Sadeghi, Naghme Mokhber, Majid Ghayour-Mobarhan, Gordon A A FernsA double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depressionJ Complement Integr Med.(2016 Jun 1)
Weight - Shahin Akhondzadeh, Seyed-Ali Mostafavi, Seyed Ali Keshavarz, Mohammad Reza Mohammadi, Saeed Hosseini, Mohammad Reza EshraghianA placebo controlled randomized clinical trial of Crocus sativus L. (saffron) on depression and food craving among overweight women with mild to moderate depressionJ Clin Pharm Ther.(2020 Feb)
Sexual Function - Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, Jamshidi A, Ashrafi M, Mansouri P, Ghaeli P, Akhondzadeh SSaffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled studyHum Psychopharmacol.(2013 Jan)
Depression Symptoms - Mohammad Ahmadpanah, Fatemeh Ramezanshams, Ali Ghaleiha, Shahin Akhondzadeh, Dena Sadeghi Bahmani, Serge BrandCrocus Sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders-a double-blind, randomized intervention studyPsychiatry Res.(2019 Dec)
Depression Symptoms - Gholamali Jelodar, Zahra Javid, Ali Sahraian, Sina JelodarSaffron improved depression and reduced homocysteine level in patients with major depression: A Randomized, double-blind studyAvicenna J Phytomed.(Jan-Feb 2018)
Depression Symptoms - Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh SCrocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trialPhytomedicine.(2006 Nov)
Depression Symptoms - Nazila Shahmansouri, Mehdi Farokhnia, Seyed-Hesammeddin Abbasi, Seyed Ebrahim Kassaian, Ahmad-Ali Noorbala Tafti, Amirhossein Gougol, Habibeh Yekehtaz, Saeedeh Forghani, Mehran Mahmoodian, Sepideh Saroukhani, Akram Arjmandi-Beglar, Shahin AkhondzadehA randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patientsJ Affect Disord.(2014 Feb)
Depression Symptoms - Akhondzadeh B, Ghoreishi S, Noorbala A, Akhondzadeh S, Rezazadeh SPetal and Stigma of Crocus sativus L. in the Treatment of Depression: A Pilot Double - blind Randomized Trial J Med Plants.()
Depression Symptoms - Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh SComparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trialProg Neuropsychopharmacol Biol Psychiatry.(2007 Mar 30)
Depression Symptoms - Ladan Kashani, Sophia Esalatmanesh, Farzaneh Eftekhari, Samrand Salimi, Tahereh Foroughifar, Farnaz Etesam, Hamideh Safiaghdam, Ehsan Moazen-Zadeh, Shahin AkhondzadehEfficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trialArch Gynecol Obstet.(2018 Mar)
Depression Symptoms - Adrian L Lopresti, Stephen J Smith, Sean D Hood, Peter D DrummondEfficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled studyJ Psychopharmacol.(2019 Nov)
Depression Symptoms - A A Noorbala, S Akhondzadeh, N Tahmacebi-Pour, A H JamshidiHydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trialJ Ethnopharmacol.(2005 Feb 28)
Depression Symptoms - Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi FComparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial ISRCTN45683816BMC Complement Altern Med.(2004 Sep 2)
Depression Symptoms - Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, Amini H, Fallah-Pour H, Jamshidi AH, Khani MCrocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trialPhytother Res.(2005 Feb)
Depression Symptoms - Ali Sahraian, Sina Jelodar, Zahra Javid, Arash Mowla, Laaya AhmadzadehStudy the effects of saffron on depression and lipid profiles: A double blind comparative studyAsian J Psychiatr.(2016 Aug)
Alzheimer's Disease Symptoms - Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi ASaffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trialJ Clin Pharm Ther.(2010 Oct)
Alzheimer's Disease Symptoms - Mehdi Farokhnia, Mehdi Shafiee Sabet, Negar Iranpour, Amirhossein Gougol, Habibeh Yekehtaz, Roozbeh Alimardani, Farzaneh Farsad, Maryam Kamalipour, Shahin AkhondzadehComparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trialHum Psychopharmacol.(2014 Jul)
Alzheimer's Disease Symptoms - Akhondzadeh S, Shafiee Sabet M, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SS, Yousefi MH, Alimardani R, Jamshidi A, Rezazadeh SA, Yousefi A, Zare F, Moradi A, Vossoughi AA 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's diseasePsychopharmacology (Berl).(2010 Jan)
Blood glucose - Armaghan Moravej Aleali, Reza Amani, Hajieh Shahbazian, Frough Namjooyan, Seyed Mahmoud Latifi, Bahman CheraghianThe effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double-blind clinical trialPhytother Res.(2019 Jun)
Blood glucose - Paria Azimi, Reza Ghiasvand, Awat Feizi, Mitra Hariri, Behnoud AbbasiEffects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes PatientsRev Diabet Stud.(Fall-Winter 2014)
Blood glucose - Fatemeh Ebrahimi, Amirhossein Sahebkar, Naheed Aryaeian, Naseh Pahlavani, Soudabeh Fallah, Nariman Moradi, Davoud Abbasi, Agha Fatemeh HosseiniEffects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled TrialDiabetes Metab Syndr Obes.(2019 Oct 14)
sICAM-1 - Paria Azimi, Reza Ghiasvand, Awat Feizi, Javad Hosseinzadeh, Maryam Bahreynian, Mitra Hariri, Hossein Khosravi-BoroujeniEffect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trialBlood Press.(2016 Jun)
Low-density lipoprotein (LDL) - Amatto PPG, Chaves L, Braga GG, Carmona F, Pereira AMSEffect of Crocus sativus L. (saffron) and crocin in the treatment of patients with type-2 diabetes mellitus: A systematic review and meta-analysis.J Ethnopharmacol.(2023-Sep-29)
TNF-Alpha - Asbaghi O, Sadeghian M, Sadeghi O, Rigi S, Tan SC, Shokri A, Mousavi SMEffects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta-analysis.Phytother Res.(2021-Jan)
Oxidative Stress Biomarkers - Abedi A, Ghobadi H, Sharghi A, Iranpour S, Fazlzadeh M, Aslani MREffect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials.Front Med (Lausanne).(2023)
Urea - Milajerdi A, et alThe effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trialJournal of Nutrition & Intermediary Metabolism.()
Erections - Hossein Mohammadzadeh-Moghadam, Seyed Mohammad Nazari, Ali Shamsa, Mohammad Kamalinejad, Habibollah Esmaeeli, Amir Abbas Asadpour, Abdoljavad KhajaviEffects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics: A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled TrialJ Evid Based Complementary Altern Med.(2015 Oct)
Depression Symptoms - Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh SEffect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trialPsychopharmacology (Berl).(2012 Oct)
Erections - Maleki-Saghooni N, Mirzaeii K, Hosseinzadeh H, Sadeghi R, Irani MA systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters.Avicenna J Phytomed.(2018 May-Jun)
Erections - Ali Shamsa, Hossein Hosseinzadeh, Mahmood Molaei, Mohammad Taghi Shakeri, Omid RajabiEvaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot studyPhytomedicine.(2009 Aug)
Hemoglobin - Modaghegh MH, Shahabian M, Esmaeili HA, Rajbai O, Hosseinzadeh HSafety evaluation of saffron (Crocus sativus) tablets in healthy volunteersPhytomedicine.(2008 Dec)
Blood Clotting - Hossein Ayatollahi, Atefeh Ordoei Javan, Mohammad Khajedaluee, Masood Shahroodian, Hossein HosseinzadehEffect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteersPhytother Res.(2014 Apr)
Vaginal Delivery Rate - Roghaieh Sadi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Yousef Javadzadeh, Afkham Ahmadi-BonabiEffect of Saffron (Fan Hong Hua) On the Readiness of The Uterine Cervix In Term Pregnancy: A Placebo-Controlled Randomized TrialIran Red Crescent Med J.(2016 Jun 20)
Weight - Tahmasbi F, Araj-Khodaei M, Mahmoodpoor A, Sanaie SEffects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2022-Sep)
Low-density lipoprotein (LDL) - Karimi-Nazari E, et alEffect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trialClin Nutr ESPEN.()
Sperm Count - Elham Karimi-Nazari, Azadeh Nadjarzadeh, Roghayyeh Masoumi, Ameneh Marzban, Seyed Ahmad Mohajeri, Nahid Ramezani-Jolfaie, Amin Salehi-AbargoueiEffect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trialClin Nutr ESPEN.(2019 Dec)
Low-density lipoprotein (LDL) - Babak Roshanravan, Saeed Samarghandian, Milad Ashrafizadeh, Alireza Amirabadizadeh, Farhad Saeedi, Tahereh FarkhondehMetabolic Impact of Saffron and Crocin: An Updated Systematic and Meta-Analysis of Randomised Clinical TrialsArch Physiol Biochem.(2020 Feb 4)
Intraocular Pressure - Fernando Cardona, Francisco J Tinahones, Eduardo Collantes, Eduardo Garcia-Fuentes, Alejandro Escudero, Federico SoriguerResponse to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV clusterJ Rheumatol.(2005 May)
Serum T3 - Bentolhoda Mousavi, Seyedeh Zahra Bathaie, Farbod Fadai, Zabihollah Ashtari, Neda Ali Beigi, Sara Farhang, Sara Hashempour, Nasim Shahhamzei, Hamid HeidarzadehSafety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophreniaAvicenna J Phytomed.(Sep-Oct 2015)
Anxiety Symptoms - Jafarnia N, et alEffect of Saffron (Crocus sativus L.) as an Add-On Therapy to Sertraline in Mild to Moderate Generalized Anxiety Disorder: A Double Blind Randomized Controlled TrialArch Neurosci.()
Depression Symptoms - Sue Gessler, Michael King, Alessandra Lemma, Julie Barber, Louise Jones, Susan Dunning, Val Madden, Stephen Pilling, Rachael Hunter, Peter Fonagy, Karen Summerville, Nicola MacDonald, Adeola Olaitan, Anne LanceleyStepped approach to improving sexual function after gynaecological cancer: the SAFFRON feasibility RCTHealth Technol Assess.(2019 Feb)
TNF-Alpha - Zahra Hamidi, Naheed Aryaeian, Jamileh Abolghasemi, Fatemeh Shirani, Mahsa Hadidi, Soudabeh Fallah, Nariman MoradiThe effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trialPhytother Res.(2020 Jul)
Seminal Motility - Mohammad Heidary, Sepideh Vahhabi, Jahanbakhsh Reza Nejadi, Bahram Delfan, Mehdi Birjandi, Hossein Kaviani, Soudabeh GivradEffect of saffron on semen parameters of infertile menUrol J.(Fall 2008)
Seminal Motility - Safarinejad MR, Shafiei N, Safarinejad SA prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermiaPhytother Res.(2011 Apr)
C-Reactive Protein (CRP) - Seyed Ahmad Hosseini, Marzie Zilaee, Maryam Haddadzadeh Shoushtari, Mohammad Ghasemi DehcheshmehAn evaluation of the effect of saffron supplementation on the antibody titer to heat-shock protein (HSP) 70, hsCRP and spirometry test in patients with mild and moderate persistent allergic asthma: A triple-blind, randomized placebo-controlled trialRespir Med.(2018 Dec)
Blood Pressure - Marzie Zilaee, Seyed Ahmad Hosseini, Sima Jafarirad, Farhad Abolnezhadian, Bahman Cheraghian, Foroogh Namjoyan, Ataollah GhadiriAn evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trialRespir Res.(2019 Feb 22)
Hip Circumference - Soukhtanloo M, et alEffect of saffron on serum leptin levels in patients with metabolic syndrome, a double-blind, randomized and placebo-controlled trial studyProg Nutr.()
Hip Circumference - Tayebe Kermani, Maedeh Zebarjadi, Hassan Mehrad-Majd, Seyed-Reza Mirhafez, Maryam Shemshian, Faezeh Ghasemi, Elham Mohammadzadeh, Seyed Hadi Mousavi, Abdolreza Norouzy, Toktam Moghiman, Akram Sadeghi, Gordon Ferns, Amir Avan, Elaheh Mahdipour, Majid Ghayour-MobarhanAnti-Inflammatory Effect of Crocus sativus on Serum Cytokine Levels in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Placebo- Controlled TrialCurr Clin Pharmacol.(2017)
Oxidative Stress Biomarkers - Tayyebeh Kermani, Seyyed Hadi Mousavi, Maryam Shemshian, Abdolreza Norouzy, Mohsen Mazidi, Atefeh Moezzi, Toktam Moghiman, Majid Ghayour-Mobarhan, Gordon A FernsSaffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trialAvicenna J Phytomed.(Sep-Oct 2015)
Depression Symptoms - Mansoor Shakiba, Ehsan Moazen-Zadeh, Ahmad Ali Noorbala, Morteza Jafarinia, Parisa Divsalar, Ladan Kashani, Nazila Shahmansouri, Abbas Tafakhori, Hannaneh Bayat, Shahin AkhondzadehSaffron ( Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trialAvicenna J Phytomed.(Nov-Dec 2018)
Short-Term Memory (Simple) - Ghodrat M, Sahraei S, Razjouyan J, Meftahi GEffects of a Saffron Alcoholic Extract on Visual ShortTerm Memory in Humans: a Psychophysical StudyNeurophysiol .()
Depression Symptoms - Magda Tsolaki, Elina Karathanasi, Ioulietta Lazarou, Kostas Dovas, Eleni Verykouki, Anastasios Karacostas, Kostas Georgiadis, Anthoula Tsolaki, Katerina Adam, Ioannis Kompatsiaris, Zacharias SinakosEfficacy and Safety of Crocus sativus L. in Patients with Mild Cognitive Impairment: One Year Single-Blind Randomized, with Parallel Groups, Clinical TrialJ Alzheimers Dis.(2016 Jul 27)
Estrogen - Fukui H, Toyoshima K, Komaki RPsychological and neuroendocrinological effects of odor of saffron (Crocus sativus)Phytomedicine.(2011 Jun 15)
PMS Symptoms - Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, Akhondzadeh SCrocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trialBJOG.(2008 Mar)
PMS Symptoms - Beiranvanda S, et alThe effect of Crocus sativus (saffron) on the severity of premenstrual syndromeEur J Integr Med.()
Blood glucose - Mansoori P, et alA Randomized, Double-blind, Placebo - controlled Study of Safety of the Adjunctive Saffron on Sexual Dysfunction Induced by a Selective Serotonin Reuptake InhibitorJ Med Plant .()
Depression Symptoms - Hausenblas HA, Saha D, Dubyak PJ, Anton SDSaffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trialsJ Integr Med.(2013 Nov)
Sexual Function - Ranjbar H, Ashrafizaveh AEffects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis.Avicenna J Phytomed.(2019 Sep-Oct)
Attention - Sara Baziar, Ali Aqamolaei, Ebrahim Khadem, Seyyed Hosein Mortazavi, Sina Naderi, Erfan Sahebolzamani, Amirhosein Mortezaei, Shakiba Jalilevand, Mohammad-Reza Mohammadi, Mahsa Shahmirzadi, Shahin AkhondzadehCrocus sativus L. Versus Methylphenidate in Treatment of Children with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot StudyJ Child Adolesc Psychopharmacol.(2019 Apr)
Creatinine - Fatemeh Ebrahimi, Naheed Aryaeian, Naseh Pahlavani, Davood Abbasi, Agha Fatemeh Hosseini, Soudabeh Fallah, Nariman Moradi, Iraj HeydariThe effect of saffron ( Crocus sativus L.) supplementation on blood pressure, and renal and liver function in patients with type 2 diabetes mellitus: A double-blinded, randomized clinical trialAvicenna J Phytomed.(Jul-Aug 2019)
Erections - Safarinejad MR, Shafiei N, Safarinejad SAn open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatmentInt J Impot Res.(2010 Jul-Aug)
Visual acuity (VA) - Falsini B, Piccardi M, Minnella A, Savastano C, Capoluongo E, Fadda A, Balestrazzi E, Maccarone R, Bisti SInfluence of saffron supplementation on retinal flicker sensitivity in early age-related macular degenerationInvest Ophthalmol Vis Sci.(2010 Dec)
Cancer Metastasis - Azar Hosseini, Seyed Hamed Mousavi, Anis Ghanbari, Fatemeh Homaee Shandiz, Hamid Reza Raziee, Masoud Pezeshki Rad, Seyed Hadi MousaviEffect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trialAvicenna J Phytomed.(Sep-Oct 2015)
Liver Enzymes - Seyed Mohammad Mousavi, Pari Mokhtari, Omid Asbaghi, Somaye Rigi, Emma Persad, Ahmad Jayedi, Hamid Rezvani, Yahya Mahamat-Saleh, Omid SadeghiDoes saffron supplementation have favorable effects on liver function indicators? A systematic review and meta-analysis of randomized controlled trialsCrit Rev Food Sci Nutr.(2021 Mar 16)
Liver Enzymes - Motahareh Hasani, Mahsa Malekahmadi, Gholamreza Rezamand, M Dulce Estêvão, Ana Beatriz Pizarro, Hafez Heydari, Wong Chun Hoong, Omar Ahnaf Arafah, Abdul Rahman Riad Barakeh, Areej Rahman, Mona Saud K Alrashidi, Ahmed Abu-ZaidEffect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trialsDiabetes Metab Syndr.(2021 Oct 12)
Skin Dryness - Shiva Golmohammadzadeh, Mahmoud Reza Jaafari, Hossein HosseinzadehDoes saffron have antisolar and moisturizing effects?Iran J Pharm Res.(Spring 2010)
Depression Symptoms - Jamshid Tabeshpour, Farzaneh Sobhani, Seyed Alireza Sadjadi, Hossein Hosseinzadeh, Seyed Ahmad Mohajeri, Omid Rajabi, Zhila Taherzadeh, Saeid EslamiA double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depressionPhytomedicine.(2017 Dec 1)
Depression Symptoms - L Kashani, S Eslatmanesh, N Saedi, N Niroomand, M Ebrahimi, M Hosseinian, T Foroughifar, S Salimi, S AkhondzadehComparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical TrialPharmacopsychiatry.(2017 Mar)
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